Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy

Pengaruh pemberian benalu teh dan benalu mangga terhadap kadar malondialdehid serum pada tikus wistar jantan

2025-03-08T11:28:55+07:00

Tea mistletoe and mango mistletoe are plants known to possess strong antioxidant activity. The antioxidants in these plants play a role in combating free radicals, inhibiting cell oxidation, and reducing the risk of cellular damage. The active compounds present in tea and mango mistletoe have the potential to reduce malondialdehyde (MDA) levels caused by free radical exposure. This study aimed to evaluate the effect of tea and mango mistletoe (BTBM) administration on MDA levels in male Wistar rats induced with deoxycorticosterone acetate (DOCA)-salt. This study used 25 male Wistar rats, divided into five groups: normal, control (DOCA-salt), and three treatment groups receiving BTBM at doses of 50, 100, and 200 mg/kgBW. The study lasted 28 days, beginning with BTBM administration for 14 days, followed by DOCA-salt induction alongside BTBM administration from day 15 to day 28. MDA levels were measured using the Thiobarbituric Acid Reactive Substances (TBARS) method with a UV-Vis spectrophotometer at a wavelength of 531 nm. Data were statistically analyzed using one-way ANOVA, followed by a Post Hoc Tukey test to determine differences between groups. The results showed that BTBM administration at a dose of 50 mg/kgBW significantly (p<0.05) reduced MDA levels compared to the control group. Thus, it can be concluded that the combination of tea and mango mistletoe has potential as an antioxidant agent in reducing MDA levels, with 50 mg/kgBW as the optimal dose in the DOCA-salt-induced rat model.

Formulasi sediaan granul effervescent kombinasi daun salam (Syzygium polyanthum) dan daun belimbing wuluh (Averrhoa bilimbi)

2025-03-08T11:36:43+07:00

Bay leaves (Syzygium polyanthum) contain flavonoid compounds that can lower blood glucose levels. On the other hand, Starfruit Leaves (Averrhoa bilimbi) contain flavonoids in the form of flavonols that can reduce and inhibit the process of glucose absorption. This study aims to find the best effervescent granule formula by combining two active ingredients from bay leaves and starfruit leaves. Extraction from both plants were prepared using the maceration method using 96% ethanol for 5 days. The manufacture of effervescent granules uses the wet granulation method to prevent separation of the mixture components, high content uniformity distribution, and increase dissolution rate. Three formulas were made to be tested for organoleptic, water content, dissolution time, and pH, which were then compared with existing literature. Comparison of the concentration of the two active ingredients in the three formulas is 1% (F1), 2% (F2), 3% (F3). The results showed that after 7 days of storage, F1 was the most stable compared to the others. On the seventh day, F1 had organoleptic test results that were yellowish green, smelled of vanilla, and had a slightly sour sweet taste, and had a water content of 3%, a dissolving time of 2.16 minutes, and a pH of 6-7.

Pengaruh pelabelan halal obat terhadap minat beli pasien di Apotek Farmarin Kota Semarang

2025-03-08T11:27:43+07:00

Islam recommends in consuming drugs not to use haram drugs. To ensure that a generic drug and patent drug are guaranteed halal, one of them is by looking at the halal labelling on the drug packaging. However, there are still people who do not know about halal labelling on the drugs they consume. The purpose of this study was to determine the effect of halal labelling on generic drugs and patent drugs on patient buying interest at Farmarin Pharmacy Semarang. The type of research used is observation with a cross sectional method. The sampling method used was incidental sampling and 90 respondents were obtained. The research instrument used was a questionnaire regarding the effect of halal labelling on drugs on patient buying interest. The analysis method in this study uses descriptive analysis by grouping the total points of patient answers based on a Likert scale. The results showed that 57 respondents (63.3%) fell into the interval group of total answer points 41 - 50 which means very influential and the remaining 33 respondents (36.67%) fell into the interval 31 - 40 which means influential. So it can be concluded that the halal label in generic and patent medicine packaging is very influential on patient buying interest.

Hubungan rasionalitas penggunaan obat antihipertensi dengan luaran klinik di RS PKU Muhammadiyah Gamping

2025-03-08T11:51:05+07:00

Hypertension is an increase in a person's blood pressure above normal, namely systolic and diastolic blood pressure ≥140/90 mmHg. Rational use of medication can describe the health quality of hypertensive patients based on the parameters of the right indication, the right patient, the right drug and the right dose. The study aimed to determine the relationship between the rationality of using antihypertensive drugs and clinical outcomes in hypertensive patients who were hospitalized at PKU Muhammadiyah Gamping Hospital. The research method is non-experimental analytical with retrospective data collection using purposive sampling for data from January 2021-March 2024 with a sample size of 63 patients. The research results showed that the rationality of using antihypertensive drugs was based on an indication accuracy of 100%, patient accuracy of 100%, appropriate medication of 84.13% and dose suitability of 96.83%. Patients who received rational antihypertensive medication were 80.95% (51 patients) and 32 patients (50.79%) showed that blood pressure was achieved. Data analysis in research uses the Chi-Square test. The results of the Chi-square test obtained a p value = 0.096>0.05 so there is no relationship between the rationality of using antihypertensive drugs and clinical outcomes.

Kualitas hidup pasien diabetes melitus di Rumah Sakit PKU Muhammadiyah Gamping

2025-03-08T11:45:55+07:00

Quality of life is an important indicator in evaluating the success of health service interventions. Based on previous studies, data were collected through interviews and filling out the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) questionnaire to assess QOL. This study aims to describe the quality of life and examine the relationship between patient characteristics (gender, age, employment status, marital status, blood sugar levels, type of treatment, and duration of diabetes) and the quality of life of diabetes mellitus patients at PKU Muhammadiyah Gamping Hospital. The research was conducted using cross-sectional design, which required 60 samples. Sampling was done through the Purposive Sampling method with interviews using the Diabetes Quality of Life Clinical Trial Questionnaire questionnaire. The data analysis process will be carried univariate and bivariate analysis. The results of the study show that 42 (70%) respondents reported a good QOL in the "Health Pressures" domain, 32 (53.33%) respondents reported a poor QOL in the "Personal Satisfaction" domain, and 30 (50%) respondents reported both good and poor QOL in the "Treatment Effects" domain. There was a relationship between marital status characteristics and the mental health domain (p<0.05) as well as the personal satisfaction domain (p<0.05). The majority of respondents had a good quality of life and there was a relationship between marital status and the mental health and personal satisfaction domains.

Tingkat pengetahuan, persepsi, dan sikap konsumen terhadap kehalalan obat di Apotek UNISIA 24 Taman Sari Yogyakarta

2025-03-08T11:41:45+07:00

Indonesia is one of the countries with the largest Muslim population in the world. So that public awareness and knowledge related to halal product guarantees is very important, one of which is the guarantee on pharmaceutical products. The purpose of this study was to determine the high level of knowledge, perceptions, and attitudes of consumers at the UNISIA 24 Taman Sari Yogyakarta Pharmacy. The research was conducted from March to May 2023. This research is a descriptive observational type. The data collection instrument uses a questionnaire and the data results are processed using statistical analysis applications. The results showed, at the level of knowledge it was known that 53% were categorized as good, 45% were categorized as sufficient and 2% were categorized as deficient. In perception, it is known that 92% are categorized as good and 9% are categorized as sufficient, in attitude it is known that 87% of respondents are categorized as good and 13% are categorized as sufficient. Based on this, it can be concluded that the average value of the level of knowledge (77%), perception (83%) and consumer attitudes (84%) towards the halalness of drugs at the UNISIA 24 Taman Sari Yogyakarta Pharmacy is in the good category.

Analisis hubungan tingkat pengetahuan masyarakat terhadap perilaku swamedikasi nyeri rasional di Kecamatan Toribulu, Kabupaten Parigi Moutong

2025-03-08T11:41:01+07:00

People often practice self-medication for common illnesses, using modern or traditional medicines without a doctor’s prescription. Pain, a sensation signaling tissue damage, is a common reason for self-medication. This study examines the relationship between knowledge levels and rational self-medication behavior for pain in Toribulu sub-district, Parigi Moutong Regency, Central Sulawesi. Using a descriptive approach, data were collected through purposive sampling. Questionnaires, tested for validity and reliability, were distributed to 391 respondents meeting inclusion criteria. Data analysis employed SPSS 23 with the Spearman correlation test. Results show 43.5% of respondents had high knowledge levels, 36.6% had sufficient levels, and 19.9% had poor levels. Regarding self-medication behavior, 60.1% displayed good behavior, 39.9% moderate behavior, and none poor behavior. The Spearman test revealed a significant but weak positive correlation (ρ-value = .000; correlation coefficient = .244) between knowledge levels and self-medication behavior. This indicates that while higher knowledge correlates with better behavior, its influence is minimal in improving self-medication practices within the community.

The relationship between polypharmacy and the incidence of drug interactions in pediatric inpatients at the regional general hospital (RSUD) Embung Fatimah Batam city

2025-03-08T11:55:48+07:00

Polypharmacy is one of the risk factors for potential drug interactions that can cause unwanted drug reactions and can also increase the risk to pediatric patients. This study aims to see if there is a relationship between polypharmacy and the incidence of drug interactions in pediatric inpatient prescriptions that will be carried out at Embung Fatimah Regional General Hospital, Batam City. This study uses a cross-sectional method, an observational research design conducted to determine the relationship between polypharmacy as the independent variable and the incidence of drug interactions as the dependent variable, with measurements taken at a single point in time. The target population to be studied is the total number of inpatient pediatric prescriptions at Embung Fatimah Hospital as many as 440 prescriptions. The sample used in this study was taken from the affordable population with inclusion and exclusion criteria. Polypharmacy prescriptions for pediatric inpatients at Embung Fatimah Regional General Hospital (RSUD) Batam City based on the results of research from a total of 168 prescriptions there were 123 (73.2%) polypharmacy prescriptions and 45 non-polypharmacy prescriptions. Drug interactions in pediatric inpatient prescriptions at the Regional General Hospital (RSUD) Embung Fatimah Batam City based on the results of the study from a total of 168 prescriptions there were 44 prescriptions experiencing drug interactions and 124 did not experience drug interactions. There is a significant relationship between polypharmacy and the incidence of drug interactions in pediatric inpatients at Embung Fatimah Regional General Hospital (RSUD) Batam City. The Chi-Square test resulted in a P-value ≤ 0.05, indicating that the null hypothesis (H₀), which states that there is no relationship between polypharmacy and drug interactions, is rejected. Consequently, the alternative hypothesis (H₁), which states that polypharmacy is significantly associated with the incidence of drug interactions, is accepted.