Pengaruh Perbedaan Bahan Pengikat yang dikombinasikan dengan Bahan Penghancur dalam SediaanTabletHisap Ekstrak Habbatus Sauda' (Nigella sativa L.)

Authors

  • Anugerah Suciati Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Darussalam Gontor
  • Andi Sri Suriati Amal Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Darussalam Gontor
  • Lija Oktya Artanti Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Darussalam Gontor

DOI:

https://doi.org/10.21111/pharmasipha.v3i2.3381

Keywords:

binder, disintegrant, troches, habbatus sauda'

Abstract

Habbatus sauda ' (Nigella sativa L.) have been examined have the content of flavonoid compounds that act as antioxidants. In order to be utilized more effectively and efficiently, it needs to be made innovation preparations with active substances habbatus sauda '. One of the innovations of preparations that can apply habbatus sauda ' as the active substance is troches. This research was conducted to find out the influence incurred due to the difference in binders combined with disintegrant on troches dosage habbatus sauda' extract. Binders used are amylum manihot and PVP while disintegrant used is Avicel PH 102. Troches’ made in four different formulas. The method used in the manufacture of troches is wet granulation with 70% ethanol spraying. On the stage of preformulation, carried out an analysis of halal ingredients. The analysis shows the critical point of halal ingredients used in the formulation is not found. The results of the evaluation of physical properties of granule and tablet indicates that the difference in binders combined with disintegrant affect the physical properties of granule and tablet. The best formula is the Formula 3 with an average value of hardness 8,69 kg/cm3 and the fragility of 0,54%.

Downloads

Published

2019-09-24

Issue

Vol. 3 No. 2 (2019): September

Section

Articles

License

Authors who publish with this Journal agree to the following terms:

  1. Author retain copyright and grant the journal right of first publication with the work simultaneously licensed under a creative commons attribution license that allow others to share the work within an acknowledgement of the work’s authorship and initial publication of this journal.
  2. Authors are able to enter into separate, additional contractual arrangement for the non-exclusive distribution of the journal’s published version of the work (e.g. acknowledgement of its initial publication in this journal).
  3. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their websites) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published works.