https://ejournal.unida.gontor.ac.id/index.php/dmj/issue/feedDarussalam Medical Journal2025-01-01T15:00:23+07:00Journal FK UNIDA Gontorjournal@fk.unida.gontor.ac.idOpen Journal Systems<p><strong>Darussalam Medical Journal (DMJ)</strong> is a peer-reviewed and open access journal published biannually (<strong>January and July</strong>) by Faculty of Medicine, Universitas Darussalam Gontor (UNIDA Gontor). The aim of DMJ is to become a qualified scientific journal that contributes to the development of research and clinical applications in the field of health and medicine.</p> <p><strong>DMJ</strong> only accepts manuscripts written in full English and or Indonesia processes submitted original manuscript. The article not being published by other publishers. We publish three categories of papers: <strong>1). Original research articles, 2). Case report articles, </strong>and<strong> 3). Literature review.</strong> The scope of this journal includes, but is not limited to the research results of:<br /><strong>- Health education<br /></strong><strong>- Public health <br />- Basic medical science</strong><br /><strong>- Biomedical Sciences</strong><br /><strong>- Clinical Sciences</strong><br /><strong>- Health Policies</strong><br /><strong>- Islamic perspective on health & ethics</strong></p> <p><strong>Publisher</strong><br />Faculty of Medicine, Universitas Darussalam Gontor, Ponorogo, East Java, Indonesia<br />Jl. Raya Siman, Ponorogo, East Java, Indonesia, 63471<br />Email: journal@fk.unida.gontor.ac.id</p>https://ejournal.unida.gontor.ac.id/index.php/dmj/article/view/13421Analysis of Differences in Work Fatigue based on Gas Station Operator Work Shift2024-12-21T14:44:09+07:00Thariq Ridhathariqridha11@gmail.comRatih Andhikathariqridha11@gmail.com<p>Operators of public refueling stations (SPBU) are exposed to continuous fatigue obtained after work where one of the factors is excessive working hours. Operators at three Ponorogo gas stations have three different work shifts, where the working hours between the three work shifts are different, with night shifts that have the longest working hours, namely 10 working hours, and day shifts with the fastest working hours, namely 7 working hours. Excessive working hours can result in negative effects on gas station operators, including increased fatigue and unhealthy living behaviors, reduced performance and reaction time, thus increasing the likelihood of injury and accidents. The purpose of this study was to look for differences in work fatigue between the three work shifts applied by ponorogo regency gas stations. Researchers used random sampling to 46 operators at 3 gas stations in Ponorogo. Data collection techniques use the Sweedish Occupational Fatigue Inventory (SOFI). The analysis used the Annova One-way test (p<0.005). The results showed a significant difference in work fatigue between the three work shifts with (p-value <0.005). The conclusion was the difference in work fatigue of gas station operators between the three work shifts, with the highest fatigue rate in night shifts.</p>2025-01-01T00:00:00+07:00Copyright (c) 2025 Darussalam Medical Journalhttps://ejournal.unida.gontor.ac.id/index.php/dmj/article/view/13468Dermatitis Kontak Alergi Akibat Bahan Kosmetik2024-12-25T09:09:02+07:00Osdatilla Esa Putrifarhanahalimarusyda@unida.gontor.ac.idHarijono Kariosentonoharijonokariosentono@fk.unida.gontor.ac.id<p><span class="fontstyle0">Allergic contact dermatitis is an inflammatory skin reaction due to direct skin contact with an allergen. Allergic contact dermatitis occurs due to the presence of reactive compounds that trigger an innate and adaptive immune response. The incidence of contact dermatitis is higher in women compared to men, as women tend to be more exposed to cosmetic ingredients and personal care products. Almost all cosmetic ingredients can cause allergic contact dermatitis. The diagnosis of DKA begins with a history taking that focuses on a history of exposure to the causative agent and a family history of possible atopy, as well as<br>a clinical assessment that follows the progression of the disease over time. The definitive treatment of allergic contact dermatitis involves identifying and avoiding the underlying cause. Patients should be educated about the substance they are allergic to and advised on how to avoid further exposure to the substance. Topical corticosteroids have been shown to be effective for the treatment of contact dermatitis if the underlying allergen has been avoided. The prognosis of patients with contact dermatitis depends on the cause and lifestyle. Isolated cases often resolve if exposure to the causative agent is stopped. Treatment of the underlying skin condition (e.g., atopic dermatitis, psoriasis) should also be optimized.</span> </p>2025-01-01T00:00:00+07:00Copyright (c) 2024 Darussalam Medical Journalhttps://ejournal.unida.gontor.ac.id/index.php/dmj/article/view/13466Regulasi Transkripsi dan Pasca Transkripsi pada Ekspresi Gen2024-12-25T09:00:33+07:00Nurul Hidayahnurulhi226@gmail.com<p><span class="fontstyle0">Transcription and post-transcription regulation is a fundamental process in controlling gene expression that allows cells to adapt to environmental changes<br>while maintaining homeostasis. Disruption of this regulation can lead to various genetic diseases, including cancer and neurodegenerative disorders. The aim of this article is to examine the mechanisms of transcriptional and posttranscriptional regulation, and their implications in molecular biology and biomedicine. The article uses a literature review approach, by collecting data from PubMed, ScienceDirect, and NCBI databases. Analyses were conducted to identify key elements, such as promoters, enhancers, silencers, RNA polymerase II, as well as transcription stages, including initiation, elongation, and termination, to post-transcriptional mechanisms such as capping, tailing, and splicing. The review shows that transcription regulation starts from the formation of a preinitiation complex involving transcription factors and RNA polymerase II. During elongation, RNA synthesis is carried out with a high degree of processivity. At the post-transcription stage, modifications such as the addition of 7-methylguanosine at the 5‘ end and polyadenylation at the 3’ end increase the stability of the mRNA. In addition, splicing mechanisms allow the formation of different proteins from a single gene. This regulation ensures that gene expression occurs at the right time, location and amount as required by the cell. At the post-transcription stage, modifications such as the addition of 7-methylguanosine at the 5‘ end and polyadenylation at the 3’ end increase the stability of the mRNA. Splicing mechanisms allow the formation of different proteins from a single gene. This regulation ensures that gene expression occurs at the right time, location, and amount according to the needs of the cell.</span> </p>2025-01-01T00:00:00+07:00Copyright (c) 2024 Darussalam Medical Journalhttps://ejournal.unida.gontor.ac.id/index.php/dmj/article/view/13464Peran Vitamin D pada Urtikaria2024-12-25T08:37:19+07:00Lifesia Natali Lidjajaharijonokariosentono@fk.unida.gontor.ac.idHarijono Kariosentonoharijonokariosentono@fk.unida.gontor.ac.id<p><span class="fontstyle0">Urticaria (hives) is a skin reaction in the form of a rash, patches or bumps that appear red and itchy. Urticaria is divided into two based on the duration of occurrence, which is acute urticarial (AU) with a duration of <6 weeks and chronic urticaria (CU) with a duration of more than 6 weeks. Acute urticaria is often associated with infection or food or drug intake. Chronic urticaria can occur spontaneously, known as chronic spontaneous urticaria (CSU), when no specific trigger is found. Chronic urticaria can also be associated with systemic disorders or can be induced by obvious stimuli, called chronic induced urticaria (CIndU).Vitamin D is a potential immunomodulator as an alternative therapy for urticaria. The role of vitamin D by modulating the immune system through its active metabolite 1,25(OH)2D, which is indicated by the presence of vitamin D receptors on T cells, B cells, macrophages, monocytes and dendritic cells. Vitamin D supplementation in patients with CU who were deficient in vitamin D significantly reduced the severity of the disease. In patients with vitamin D deficiency, the dose of administration is 7000-10,000 IU/day (175- 250 mcg/day) or 50,000 IU/week (1250 mcg/week), with a duration of 1-3 months and monitoring of serum vitamin D levels at least 8-12 weeks after the first dose is given. The use of high doses of vitamin D (28000 IU/week) as adjunctive therapy has been shown to reduce the severity of CU symptoms and the dose of allergy medication.</span> </p>2025-01-01T00:00:00+07:00Copyright (c) 2024 Darussalam Medical Journalhttps://ejournal.unida.gontor.ac.id/index.php/dmj/article/view/13462Perawatan Kulit pada Bayi Preterm dengan Pemberian Minyak Topikal2024-12-25T08:17:33+07:00Azhar Arrosyidharijonokariosentono@fk.unida.gontor.ac.idEndra Yustin Ellistasariharijonokariosentono@fk.unida.gontor.ac.idHarijono Kariosentonoharijonokariosentono@fk.unida.gontor.ac.id<p>Preterm birth is a baby born at less than 37 weeks. The skin of preterm babies is different from the skin of aterm babies. Preterm babies have thinner skin that is more susceptible to infection, irritation, fluid loss, electrolyte imbalance and trauma. Good skin care is one of the important components in caring for preterm infants. The use of coconut oil as a topical treatment in preterm infants has positive effects. Coconut oil is made of fatty acids that serve to replace lost lipids in the skin barrier. Coconut oil is also antiseptic and antioxidant. In addition to coconut oil, there is also sunflower seed oil. Topical administration of sunflower seed oil to preterm infants has the effect of better skin integrity and lower risk of nosocomial infection. Sunflower seed oil has a linoleic acid component of about 60%. Linoleic acid has been shown to be a necessary fatty acid to maintain the normal barrier function of the epidermis. The composition and fatty acid content of both oils are the main factors that have a positive effect on the skin.</p>2025-01-01T00:00:00+07:00Copyright (c) 2024 Darussalam Medical Journal